Bliss.

Bliss.

Thursday, March 29, 2012

The Bizarre Brain.

Prosopagnosia 
Prosopagnosia is a disorder of face perception where the ability to recognize faces is impaired, while the ability to recognize other objects may be relatively intact. The term originally referred to a condition following acute brain damage, but a congenital form of the disorder has been proposed, which may be inherited by about 2.5% of the population. The specific brain area usually associated with prosopagnosia is the fusiform gyrus.
Few successful therapies have so far been developed for affected people, although individuals often learn to use 'piecemeal' or 'feature by feature' recognition strategies. This may involve secondary clues such as clothing, gait, hair color, body shape, and voice. Because the face seems to function as an important identifying feature in memory, it can also be difficult for people with this condition to keep track of information about people, and socialize normally with others.

The Capgras Syndrome
The Capgras delusion theory (or Capgras syndrome) is a disorder in which a person holds a delusion that a friend, spouse, parent, or other close family member has been replaced by an identical-looking impostor. The Capgras delusion is classified as a delusional misidentification syndrome, a class of delusional beliefs that involves the misidentification of people, places, or objects. It can occur in acute, transient, or chronic forms. Cases in which patients hold the belief that time has been "warped" or "substituted" have also been reported.

Many researchers think that Capgras syndrome is actually the result of something wrong with the brain, an organic cause. They look for lesions on the brain, signs of atrophy and other cerebral dysfunction. Although Capgras syndrome is usually seen in people who have psychotic disorders, more than a third of Capgras patients have signs of head trauma [source: Hirstein and Ramachandran]. Many Capgras patients also have other organic conditions, like epilepsy or Alzheimer's.
Still more doctors and researchers combine the idea of both a physical and a cognitive cause. There's something wrong with the brain, but why and how is Capgras syndrome occurring because of it? Maybe the organic cause leads to feelings of disconnectedness that lead to Capgras syndrome. Maybe it's too tough for people with a brain lesion to update memories when they see a person and the person looks slightly different. Your body is having a strange experience and your brain scrambles for a way to explain it.
Somewhere, the brain isn't communicating when it should be. This breakdown of communication might be happening between the part of the brain that processes the visual information for faces and the part that controls the limbic system's emotional response.
The argument seems to come down to whether Capgras syndrome is a problem of perception or of some other process, like memory. Hirstein and Ramachandran proposed that Capgras syndrome is a problem of "memory management." They give this example: Think of a computer. You make a new file and save it. When you want that information, you open the old file, add to it, save and close it again. Perhaps people with Capgras keep creating new files instead of accessing the old one, so that when you leave the room and re-enter, you are a new person, a person who looks like the one who left, but slightly different -- maybe your ears look bigger, or your hair a different hue. There's still a lot that science doesn't know about the human memory.
Some studies have also shown blind people with Capgras syndrome -- their delusion extends to the voice of a person, thinking that the voice is a voice of an impostor, instead of the face, so perhaps it isn't a face-processing problem at all. Other studies have shown people who were convinced by looking at a person that that person was an impostor, but they recognized the person's voice on the phone.



Fregoli Syndrome
The Fregoli delusion or the delusion of doubles is a rare disorder in which a person holds a delusional belief that different people are in fact a single person who changes appearance or is in disguise. The syndrome may be related to a brain lesion, and is often of a paranoid nature with the delusional person believing themselves persecuted by the person they believe is in disguise.
A person with the Fregoli delusion can also inaccurately replicate places, objects, and events. This disorder can be explained by "associative nodes." The associative nodes serve as a biological link of information about other people with a particular familiar face (to the patient). This means that any face that is similar to a recognizable face to the patient, the patient will recall that face as the person they know.
The condition is named after the Italian actor Leopoldo Fregoli who was renowned for his ability to make quick changes of appearance during his stage act.
P. Courbon and G. Fail first reported the condition in a 1927 paper (Syndrome d’illusion de Frégoli et schizophrénie). They described a 27-year-old woman living in London who believed she was being persecuted by two actors she often saw at the theatre. She believed these people pursued her closely, taking the form of people she knew or met.

Thatcher Effect
The Thatcher effect or Thatcher illusion is a phenomenon where it becomes difficult to detect local feature changes in an upside down face, despite identical changes being obvious in an upright face. It is named after British former Prime Minister Margaret Thatcher on whose photograph the effect has been most famously demonstrated. This was originally created by Peter Thompson, (Thompson, 1980).
The effect is illustrated by two originally identical photos, which are inverted. The second picture is obviously altered so that the eyes and mouth are vertically flipped, though the changes are not immediately obvious until the image is viewed in normal orientation.
This is thought to be due to specific psychological processes involved in face perception which are tuned especially to upright faces. Faces seem unique despite the fact that they are very similar. It has been hypothesised that we develop specific processes to differentiate between faces that rely as much on the configuration (the structural relationship between individual features on the face) as the details of individual face features, such as the eyes, nose and mouth. When a face is upside down, the configural processing cannot take place, and so minor differences are more difficult to detect.
This effect is not present in people who have some forms of prosopagnosia, a disorder where face processing is impaired, usually acquired after brain injury or illness. This suggests that their specific brain injury may damage the process that analyses facial structures.
Rhesus monkeys also show the Thatcher effect (Adachi, et al., 2009), raising the possibility that some brain mechanisms involved in processing faces may have evolved in a common ancestor 30+ million years ago.
(I found the pictures related to these rather grotesque, so I decided against including them in the blog)


This is my 100th blog post! Here's to a 100 more hundreds! :D Or maybe a Googol more posts!

It's Been a Year!

A year ago, around this time, I was in Red Fort, Delhi. With Pa, Vidhathri and Lokesh. 365 whole days have passed. Seems unbelievable. My Boards were over and I had the time of my life.

Here's to many more such wonderful journeys to unexplored territories that enrich and rejuvenate me with the awesome-est of companions! :)


Wednesday, March 28, 2012

Beatles.

I read a book by John Lennon's first wife, Cynthia a few months back. Although I hadn't heard anything by the Beatles until then, I read it, just to know them. It was a good read and rather sad. The effect of drugs and Yoko Ono on his life was devastating to read (at least from the perspective of Cynthia).

Lennon and Cynthia, Post Marriage

And I heard 'Hey Jude' today. I loved it. Better than 'Love Me Do'.. :)

We Found Love

My current favourite song. Rather, favourite tune, since its quite repetitive.
Term exam on Saturday. I may go see Hunger Games with Priyanka <3

So my ideas for Google Science Fair didn't really work out. Oh well. I'll send in my project anyway.

Why did I go to IISc?
I suddenly felt the urge to see the premier research Institute in Bangalore. I missed the open day as I was writing my Sanskrit PU exam. How was it?

Nothing like I had imagined. I was lucky to see the famed labs. I, a random stranger (no, a 11th grade science enthusiast, actually) could walk around the campus. What did I see?

The MBU department which requires knowledge of Ubuntu, MicroB. They take a protein (say myosin) and analyze its structure which can help understand its function and how it can help man (in medicine and pharma). 

Then I visited Prof. Dipshika's lab. Here they are currently studying Salmonella Typhi and trying to develop a more effective vaccine. One way to study these organims is to analyze their DNA, use Biotechnology (PCR and Recombination Technology) to remove a gene and study its implications. Using this data they develop a vaccine. Also they study Anti Microbial Proteins which have different mechanisms of attack.

Next I met Dr. Vijayalakshmi Ravindranath (Centre for Neuroscience, IISc and also founder of NBRC). Obviously my request was turned down although I tried my best. Still, I met her, I spoke to her and one 'no' cannot change my goals.

The Idea behind the visit was try and 'volunteer' at any of the ongoing research projects there. But this did not materialize because IISc has its own criteria for selection of students (KVPY, Integrated PhD, PhD, Summer Fellowship, etc). And a 11th grader does not figure among them. Yes, I was disappointed, but then again, I must be happy that I could see the place, observe and meet a few PhD students who gladly explained about their research projects. In fact, on my second visit, some students were willing to have me 'help around' or rather observe, but that wasn't meant to be.

Oh and I spoke in the assembly. About? I spoke on Pi day (Hint Hint: Tim the Beaver :P) , Capgras Syndrome and I ended it with a RD joke.

Consecutive All-nighters ARE possible. I'm the proof.

Btw I some one in the assembly read about the record 'for going without sleep for the longest period'

Randy Gardner holds the scientifically documented record for the longest period a human being has intentionally gone without sleep not using stimulants of any kind. In 1964—as a 17-year-old high school student in San Diego, California—Gardner stayed awake for 264 hours (eleven days)
It is often claimed that Gardner's experiment demonstrated that extreme sleep deprivation has little effect, other than the mood changes associated with tiredness (mood swings, short temper, loss of concentration).[6] This is primarily due to a report by researcher William Dement, who stated that on the tenth day of the experiment, Gardner had been, among other things, able to beat Dement at pinball.
However, Lt. Cmdr. John J. Ross, who monitored his health, reported serious cognitive and behavioral changes. These included moodiness, problems with concentration and short term memory, paranoia, and hallucinations. On the fourth day he had a delusion that he was Paul Lowe winning the Rose Bowl, and that a street sign was a person. On the eleventh day, when he was asked to subtract seven repeatedly, starting with 100, he stopped at 65. When asked why he had stopped, he replied that he had forgotten what he was doing.[1]
On his final day, Gardner presided over a press conference where he spoke without slurring or stumbling his words and in general appeared to be in excellent health. "I wanted to prove that bad things didn't happen if you went without sleep," said Gardner. "I thought, 'I can break that (Peter Tripp's 1959) record and I don't think it would be a negative experience.'"

I think the most interesting article was about Jesus being a superhuman with 'triple helix DNA' (How does that look??).

Triple-stranded DNA was a common hypothesis in the 1950s when scientists were struggling to discover DNA's true structural from. Watson and Crick (who later won the Nobel Prize for their double-helix model) originally considered a triple-helix model, as did Pauling and Corey, who published a proposal for their triple-helix model in the 1953 scientific journal Nature, as well as fellow scientist Fraser. However, Watson and Crick soon identified several problems with these models:
  1. Negatively charged phosphates near the axis will repel each other, leaving the question as to how the three-chain structure would stay together.
  2. In a triple-helix model (specifically Pauling and Corey's model), some of the van der Waals distances appear to be too small.

His species possesses phenomenal supernatural abilities, including telekinesis, levitation (walking on water), telepathy (knowing people’s thoughts), healing, etc.

But it could all be mere speculation for all I know.

Sunday, March 11, 2012

Was ich denke

I hope the quiz thing succeeds.
I shouldn't have been so hopeful about IISc. 
But it was a great experience. Im happy I interacted with a few researchers.

What to do when you HATE somebody but you can't really pinpoint why? And to add to that, your ventures might require their presence? AARGH. I know its horrid but I probably hate this person more than Hori (of Carmel. The only person I really hate) but I don't know why. Or maybe...

And Yesterday, I felt happy. A lot of things cleared up. Im clear about what I feel, atleast about this. Im happy for the person. I guess I always knew the truth deep down, I probably didn't listen to myself. And I don't think all that matters, does It?

I havent written anything good in a long time. My NRI story is lame, I think. I wrote an argument to some article in BM by Aseem Chabbra. I figured that I know a lot about Bollywood. I liked my analysis.

Its basically about what we define Bollywood to be. People say Jab We Met, EMAET, PST and now Kahaani reflect the real Bollywood. But I strongly feel that such straitjacketed thinking does not represent Bollywood.
Bollywood comprises of Everything, from song and dance filled stories to Paisa vasool movies like Dabangg, OSO, Bodyguard, comedies like the Golmaal trilogy, Yash Raj romances, Akshay Kumar's acion flicks, contemplative movies like A Wednesday, Firaaq, Peepli Live and Dhobi Ghat, dark thrillers from the Bhatt camp and yet there's space for new age film makers like Anurag Kashyap, Vikramaditya Motwane and Tigmanshu Dhulia. Bollywood is large hearted enough to have all of them. They all collectively define Bollywood. It would be highly unfair to liken Bollywood to just a few budding filmmakers just to elevate Bollywood to Hollywood standards. Bwood doesn't need the comparison. We are unique, we have different stories to tell and honestly, we all like a healthy dose of song and dance. That's who we are and there's no running away from it just be comparable with Hollywood. Come to think of it, it sounds ridiculous.

(Do I sound like I know what I'm talking? 
I hope so.)

I got a haircut.


Kay bye.

Jaybee Maybe? Haha I miss Pinki.

Actually no. Lol. And No Idlis for me. They're fine though.

Its a Broken Life. Huh

Broke Laptops, Broken Mobiles, Broken DVD, Broken Glass. What hurts more is Broken Heart.